Intravenous Oxytocin Versus Oxytocin Combined with Misoprostol in the Management of the Third Stage of Labor in Vaginal Delivery

Objective: This study was aimed to compare the treatment of third stage labour in vaginal delivery between intravenous (IV) oxytocin and IV + sublingual misoprostol primigravida with singleton pregnancy. Background: Worldwide, over 290,000 women pass away each year either during pregnancy, labour, or first six weeks following delivery. The most frequent primary cause maternal mortality underdeveloped nations is still postpartum haemorrhage (PPH). To prevent atonic haemorrhage, uterotonic medications are employed. These include misoprostol, oxytocin, carbetocin, methylergometrine. Numerous studies have shown that best heat-labile agent for halting blood loss. Study Design: randomized control trial Place Duration: conducted at Federal Government Polyclinic Hospital PGMI Islamabad from November 2021 2022. Methodology: Participants included 40 cases group patients. For study, we used a single blind randomization allocate patients defined groups. Data were entered into SPSS version 23.0. P-value calculated using Chi Square test (for categorical dependent variable) t-test numerical variable). Results: Out 80 given combined combination received only oxytocin. Greater than 500 mL loss occurred more frequently (27.5% versus 17.5%) group. However, statistical significance this proportional difference not established (p-value, 0.08). total cases, indicated 18 (22.5%) experienced hemorrhage. Conclusion: According current research, work better together they do separately. In comparison alone, mean significantly lower. Keywords: Oxytocin, Misoprostol, PPH (Post partum hemorrhage)